Symbol
Name
ID

Snrnp40
small nuclear ribonucleoprotein 40 (U5)
MGI:1913835

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Mouse Phenotypes

immune system phenotype

decreased T cell proliferation

abnormal thymus development

small thymus

thymus hypoplasia

decreased DN1 thymic pro-T cell number

decreased DN4 thymocyte number

decreased B cell number

decreased NK cell number

decreased CD4-positive, alpha-beta T cell number

increased central memory CD8 positive, alpha-beta T cell number

increased effector memory CD8-positive, alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

decreased T cell number

decreased lymphocyte cell number

decreased monocyte cell number

impaired natural killer cell mediated cytotoxicity

abnormal CD4-positive, alpha-beta T cell physiology

abnormal CD8-positive, alpha-beta T cell physiology

increased circulating interferon-beta level

increased circulating interferon-gamma level

increased circulating interleukin-12 level

increased circulating interleukin-17 level

increased circulating interleukin-6 level

increased circulating tumor necrosis factor level

increased susceptibility to viral infection induced morbidity/mortality

increased susceptibility to viral infection

Availability

Mouse Genotype

Snrnp40^em1Btlr/Snrnp40^swp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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